Photo by Ryan Watts
Search Upstate South Carolina hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Check prices for these dates
Our top choices for Upstate South Carolina hotels
Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
9.6 out of 10, Exceptional, (448 reviews)
"We love staying at the Hampton Inn in Greer, SC. The staff is always kind and efficient. The rooms are always clean and comfortable. Great place to stay!"
Dawn
The price is AU$211
includes taxes & fees
18 Apr - 19 Apr
Holiday Inn Express Gaffney by IHG
Holiday Inn Express Gaffney by IHGGaffney
8.8 out of 10, Excellent, (472 reviews)
"Very clean and staff the super kind and friendly 10/10 stay"
Kevin
The price is AU$124
includes taxes & fees
3 May - 4 May
Hampton Inn Gaffney
Hampton Inn GaffneyGaffney
8.8 out of 10, Excellent, (702 reviews)
"Would stay again breakfast was amazing "
Theresa
The price is AU$135
includes taxes & fees
17 May - 18 May
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
9.0 out of 10, Wonderful, (1,151 reviews)
"Clean room and great Breakfast "
Tara
The price is AU$210
includes taxes & fees
26 Apr - 27 Apr
Inn on the Square, an Ascend Collection Hotel
Inn on the Square, an Ascend Collection HotelUptown Greenwood
9.2 out of 10, Wonderful, (734 reviews)
"Near to historic district. "
Sandra
The price is AU$183
includes taxes & fees
17 May - 18 May
Four Points by Sheraton Spartanburg
Four Points by Sheraton SpartanburgSpartanburg
9.4 out of 10, Exceptional, (479 reviews)
"Very nice hotel. Room was very clean and attractive. Gorgeous lobby! Would definitely stay here again. "
Edsel
The price is AU$184
includes taxes & fees
17 May - 18 May
Comfort Inn & Suites Greer - Greenville
Comfort Inn & Suites Greer - GreenvilleGreer
8.6 out of 10, Excellent, (779 reviews)
"The staff was very friendly, great breakfast and the room was very clean. Great stay. "
susan
The price is AU$151
includes taxes & fees
17 May - 18 May
Tru by Hilton Spartanburg
Tru by Hilton SpartanburgSpartanburg
9.2 out of 10, Wonderful, (875 reviews)
"Clean room , friendly staff , great location "
Gerad
The price is AU$170
includes taxes & fees
19 Apr - 20 Apr
AC Hotel by Marriott Spartanburg
AC Hotel by Marriott SpartanburgSpartanburg
9.4 out of 10, Exceptional, (624 reviews)
"Great location. Modern, streamlined decor. Helpful staff! "
Terry
The price is AU$246
includes taxes & fees
19 Apr - 20 Apr
The Inn at Patrick Square
The Inn at Patrick SquareClemson
9.8 out of 10, Exceptional, (831 reviews)
"Great location, great staff - loved the room! "
Eric
The price is AU$246
includes taxes & fees
26 Apr - 27 Apr
Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,011 reviews)
"Excellent stay "
Elliott
The price is AU$231
includes taxes & fees
22 Apr - 23 Apr
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
Holiday Inn Express Hotel & Suites Spartanburg-North by IHGSpartanburg
8.6 out of 10, Excellent, (902 reviews)
"Clean room, helpful staff. Great breakfast! "
Christine
The price is AU$141
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn Anderson/ Alliance Business Park
Hampton Inn Anderson/ Alliance Business ParkAnderson
9.2 out of 10, Wonderful, (832 reviews)
"Staff were so helpful , place was clean and food spots near by"
osiry
The price is AU$180
includes taxes & fees
22 Apr - 23 Apr
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
9.2 out of 10, Wonderful, (1,448 reviews)
"Everything was great at this hotel "
Karen
The price is AU$144
includes taxes & fees
19 Apr - 20 Apr
The Abernathy of Clemson
The Abernathy of ClemsonClemson
9.6 out of 10, Exceptional, (587 reviews)
"Excellent location to visit Clemson. Staff is very friendly. Rooms are clean spacious. "
Linda
The price is AU$231
includes taxes & fees
10 May - 11 May
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University AreaClemson
8.2 out of 10, Very good, (1,004 reviews)
"Easy check in / clean room / nice staff& good breakfast …well done "
HANS
The price is AU$158
includes taxes & fees
12 May - 13 May
Comfort Suites Greenville Airport
Comfort Suites Greenville AirportGreenville
9.2 out of 10, Wonderful, (1,012 reviews)
"Clean rooms, friendly staff, great location "
Brandon
The price is AU$150
includes taxes & fees
17 May - 18 May
Hampton Inn & Suites Greenville Airport, SC
Hampton Inn & Suites Greenville Airport, SCGreenville
9.2 out of 10, Wonderful, (1,001 reviews)
"The front desk staff at check in and check out were fantastic! "
Tara
The price is AU$168
includes taxes & fees
26 Apr - 27 Apr
Courtyard Greenville-Spartanburg by Marriott
Courtyard Greenville-Spartanburg by MarriottGreer
8.8 out of 10, Excellent, (656 reviews)
"Wonderful stay!"
Heather
The price is AU$187
includes taxes & fees
24 Apr - 25 Apr
Days Inn by Wyndham Anderson
Days Inn by Wyndham AndersonAnderson
8.0 out of 10, Very good, (1,015 reviews)
"Awesome place "
Tramaness
The price is AU$92
includes taxes & fees
30 Apr - 1 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Upstate South Carolina
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (68 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southeastern United States attractions
Learn more about Upstate South Carolina
Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.
Photo by Ryan Watts
Open Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews
Recent Reviews in Upstate South Carolina
Drury Inn & Suites Greenville
10/10 Excellent
More cheap accommodation in Upstate South Carolina
Best Western Greenville Airport Inn
5009 Pelham Road Greenville SC
The price is AU$99 per night from 18 Apr to 19 Apr
AU$99
18 Apr - 19 Apr
includes taxes & fees
7.8/10 Good! (1,008 reviews)
Explore a world of travel with Expedia
- Pet Friendly Hotels in Boiling Springs
- Boiling Springs Hotels
- Cabin Rentals in Clinton
- Holiday Homes in Clinton
- Spartanburg County Hotels
- Drayton Hotels
- Caravan Parks in Duncan
- Cottages in Duncan
- Duncan Hotels
- Enoree Hotels
- Fingerville Hotels
- Five Forks Hotels
- Fountain Inn Hotels
- Gray Court Hotels
- Hotels near Greenville-Spartanburg Intl.
- Greer Hotels
- Hotels near Heritage Park
- Inman Hotels
- Laurens Hotels
- Lyman Hotels
- Mauldin Hotels
- Moore Hotels
- Holiday Homes in Pauline
- Pauline Hotels
- Caravan Parks in Roebuck
- Roebuck Hotels
- Lodges in Roebuck
- Hotels near Shipwreck Cove
- Caravan Parks in Southern Shops
- Cheap Hotels in Southern Shops
- All Inclusive Hotels in Spartanburg
- Spartanburg Hotels
- Hotels near Spartanburg Regional Hospital
- Startex Hotels
- Beach Hotels in Taylors
- Family Hotels in Taylors
- Taylors Hotels
- Hotels near Tyger River Park
- Una Hotels
- Upstate South Carolina Hotels
- Wellford Hotels
- Hotels near Wofford College
- Cheap Hotels in Woodruff
- Luxury Hotels in Woodruff
- Woodruff Hotels
- Flights to Buffalo
- Flights to Fairforest
- Flights to Five Forks
- Flights to Greenville-Spartanburg Intl.
- Flights to Laurens
- Flights to Roebuck
- Flights to Simpsonville
- Flights to Southern Shops
- Flights to Spartanburg
- Flights to Una
- Flights from Donaldson Center
- Flights from Greenville Downtown
- Flights from Greenville-Spartanburg Intl.
- Flights from Denver to Upstate South Carolina
- Flights from Philadelphia to Upstate South Carolina
- Flights from Startex
- Flights from Gray Court
- Flights from Wellford
- Flights from Boiling Springs
- Flights from Taylors
- Flights from Duncan
- Flights from Adelaide (ADL) to Greenville (GSP)
- Flights from Anderson (AND) to Greenville (GMU)
- Flights from Atlanta (ATL) to Greenville (GSP)
- Flights from Mobile (BFM) to Greenville (GMU)
- Flights from Brisbane (BNE) to Greenville (GSP)
- Flights from Charlotte (CLT) to Greenville (GSP)
- Flights from Coeur d'Alene (COE) to Greenville (GSP)
- Flights from Dallas (DFW) to Greenville (GSP)
- Flights from Dillon (DLL) to Greenville (GDC)
- Flights from Delta (DTA) to Greenville (GSP)
- Flights from Ankara (ESB) to Greenville (GSP)
- Flights from Gulfport (GPT) to Greenville (GDC)
- Flights from Greenwood (GRD) to Greenville (GMU)
- Flights from Honolulu (HNL) to Greenville (GSP)
- Flights from Houston (IAH) to Greenville (GSP)
- Flights from Indianapolis (IND) to Greenville (GDC)
- Flights from Los Angeles (LAX) to Greenville (GSP)
- Flights from New York (LGA) to Greenville (GSP)
- Flights from Orlando (MCO) to Greenville (GSP)
- Flights from Melbourne (MEL) to Greenville (GSP)
- Flights from Miami (MIA) to Greenville (GDC)
- Flights from Miami (MIA) to Greenville (GMU)
- Flights from Melbourne (MLB) to Greenville (GSP)
- Flights from Chicago (ORD) to Greenville (GMU)
- Flights from Perth (PER) to Greenville (GSP)
- Flights from Rota (ROP) to Greenville (GSP)
- Flights from San Francisco (SFO) to Greenville (GSP)
- Flights from Sydney (SYD) to Greenville (GSP)
- Flights from Varginha (VAG) to Greenville (GSP)
